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Article

Role of hypothalamus-pituitary-adrenal axis modulation in the stress-resilient phenotype of DPP4-deficient rats.

Behavioural brain research - 1 Jan 2019

Golub Yulia, Schildbach Eva-Maria, Touma Chadi, Kratz Oliver, Moll Gunther H, von Hörsten Stephan, Canneva Fabio

Abstract excerpt

BACKGROUND: Dipeptidyl peptidase 4 (DPP4, CD26) is a moonlighting enzyme responsible for the proteolytic inactivation of neuropeptide Y (NPY), a peptide known for its anxiolytic effect in the central nervous system. Our previous work revealed a stress-resilient phenotype and a potentiation of short-term fear extinction in a congenic rat model deficient for DPP4 activity (DPP4mut). Here, we investigated...

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PMID: 30176267
DOI: 10.1016/j.bbr.2018.08.029

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