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Article

Behavioural profile of a new mouse model for NPY deficiency

1 Jul 2008

Abstract excerpt

The abundantly expressed neuropeptide Y (NPY) plays an important role in anxiety and stress reactivity, as exogenous NPY administration reduces anxiety-like behaviour in rodents. However, unlike the potent effects of NPY seen in pharmacological studies, two independent examinations of a genetic mouse model for NPY deficiency have shown only subtle, inconsistent and task-dependent anxiety-related phenotypes for...

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PMID: 18616565
DOI: 10.1111/j.1460-9568.2008.06306.x

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