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Article

Characterizing changes in the rate of protein-protein dissociation upon interface mutation using hotspot energy and organization.

PLoS computational biology - 1 Jan 2013

Agius Rudi, Torchala Mieczyslaw, Moal Iain H, Fernández-Recio Juan, Bates Paul A

Abstract excerpt

Predicting the effects of mutations on the kinetic rate constants of protein-protein interactions is central to both the modeling of complex diseases and the design of effective peptide drug inhibitors. However, while most studies have concentrated on the determination of association rate constants, dissociation rates have received less attention. In this work we take a novel approach by relating the changes in...

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PMID: 24039569
DOI: 10.1371/journal.pcbi.1003216
PMCID: PMC3764008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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