Article
Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2024
Sakurai Ryota, Pieruccini-Faria Frederico, Cornish Benjamin, Fraser Julia, Binns Malcolm A, Beaton Derek, Dilliott Allison Ann, Kwan Donna, Ramirez Joel, Tan Brian, Scott Christopher J M, Sunderland Kelly M, Tartaglia Carmela, Finger Elizabeth, Zinman Lorne, Freedman Morris, McLaughlin Paula M, Swartz Richard H, Symons Sean, Lang Anthony E, Bartha Robert, Black Sandra E, Masellis Mario, Hegele Robert A, McIlroy William, Montero-Odasso Manuel
Abstract excerpt
INTRODUCTION: Apolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism in neurodegenerative diseases. METHODS: Gait speed, APOE E4, cognition, and neuroimaging were assessed in 480 older adults with neurodegeneration....
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