Article
Using the ancestral recombination graph to study the history of rare variants in founder populations.
American journal of human genetics - 4 Dec 2025
Mejia-Garcia Alejandro, Diaz-Papkovich Alex, Sillon Guillaume, D'Agostino Daniela, Chong Anne-Laure, Chong George, Lo Ken Sin, Baret Laurence, Hamel Nancy, Chapdelaine Vincent, Foulkes William D, Taliun Daniel, Shapiro Adam J, Lettre Guillaume, Gravel Simon
Abstract excerpt
Gene genealogies represent the shared ancestry of a sample and are often encoded as ancestral recombination graphs (ARGs). It has recently become possible to infer these gene genealogies from sequencing or genotyping data and use them for many evolutionary and statistical genetics applications. Here, we use the ARG inference software ARG-needle and the pedigree imputation software ISGen to impute and trace the...
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