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Fine-scale structure of a whole regional population through genetics and genealogies.

Nature communications - 2 Mar 2026

Morin Gilles-Philippe, Moreau Claudia, Barry Amadou, Girard Simon L

Abstract excerpt

Population stratification can confound genetic association studies and often persists despite adjustment using principal components of common variants. Demographic history and rare variants can also contribute to this confounding. But to what extent does demographic history impact fine structure and can be detected in human populations? To address this question, we analysed the Saguenay-Lac-Saint-Jean region of...

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Identifiers

PMID: 41771909
DOI: 10.1038/s41467-026-70175-y
PMCID: PMC13066195

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