Article

Tracing the evolutionary histories of ultra-rare variants using variational dating of large ancestral recombination graphs

2026-01-12

Abstract excerpt

Ultra-rare variants dominate whole-genome sequencing datasets, yet their interpretation is limited by allele frequency, which provides little information at very low counts and is highly sensitive to uneven ancestry representation. Allele age offers an ancestry-agnostic alternative but existing methods do not scale to biobank-sized cohorts. Here we present a scalable variational algorithm for dating Ancestral Reco...

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Literature Corpus work: c12ed569-d27b-5258-b985-7d9d98f27f59
DOI: 10.64898/2026.01.07.698223

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