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A mouse-adapted Yezo virus model for antiviral testing in immunocompetent mice

2026-03-04

Abstract excerpt

Emerging tick-borne orthonairoviruses pose a growing public health threat, yet few animal models fully recapitulate human disease. Here, we report the development of a mouse-adapted Yezo virus (MA-YEZV) strain that causes lethal infection in immunocompetent mice, mirroring key clinical features of human infection, including thrombocytopenia, leukopenia, and severe liver injury. Serial passaging of YEZV in C57BL/6J...

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Identifiers and source

Literature Corpus work
695d7fa3-5f96-57b0-ac7a-df68166e1e70
DOI
10.64898/2026.03.03.709471
Open publication

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A mouse-adapted Yezo virus model for antiviral testing in immunocompetent miceDOI 10.64898/2026.03.03.709471
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