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Article

Dissecting the Role of E2 Protein Domains in Alphavirus Pathogenicity

17 Dec 2015

Abstract excerpt

UNLABELLED: Alphaviruses represent a diverse set of arboviruses, many of which are important pathogens. Chikungunya virus (CHIKV), an arthritis-inducing alphavirus, is the cause of a massive ongoing outbreak in the Caribbean and South America. In contrast to CHIKV, other related alphaviruses, such as Venezuelan equine encephalitis virus (VEEV) and Semliki Forest virus (SFV), can cause encephalitic disease. E2,...

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PMID: 26676771
DOI: 10.1128/jvi.02792-15

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