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Article

A mouse-adapted Yezo virus model for antiviral testing in immunocompetent mice.

Nature communications - 17 Mar 2026

Xu Wenbo, Wang Yuanzhi, Pan Mingming, Tan Qianqian, Jin Fangyu, Sui Liyan, Zhao Yinghua, Liu Nan, Liu Quan

Abstract excerpt

Emerging tick-borne orthonairoviruses pose a growing public health threat, yet few animal models fully recapitulate human disease. Here, we report the development of a mouse-adapted Yezo virus (MA-YEZV) strain that causes lethal infection in immunocompetent mice, mirroring key clinical features of human infection, including thrombocytopenia, leukopenia, and severe liver injury. Serial passaging of YEZV in...

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Identifiers

PMID: 41844638
DOI: 10.1038/s41467-026-70851-z
PMCID: PMC13139436

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TNF

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