Article
Mutation of a conserved lysine in the RdRp fingers domain broadly attenuates orthobunyaviruses.
Communications biology - 10 Jun 2026
Xiong Guodian, Wang Fei, Tang Jingjing, Cheng Tao, Ren Nanjie, Geng Jingke, Chen Wei, Huang Doudou, Deng Zengqin, Sun Xiang, Wang Jinglin, Yuan Zhiming, Xia Han
Abstract excerpt
Orthobunyaviruses, comprising more than 130 species, constitute a significant threat to human and animal health, yet no effective broad-spectrum treatments or vaccines are currently available. Here, we initially identified an evolutionarily constrained lysine residue, highly conserved across all 22 Orthobunyavirus serogroups, within the α30 helix of the RNA-dependent RNA polymerase (RdRp). Functional...
Read the complete abstract on PubMedTopics
- Lysine
- Animals
- RNA-Dependent RNA Polymerase
- Orthobunyavirus
- Mutation
- Humans