Article
Adjustment for Genotype Imputation Uncertainty Corrects for Inflated Type I Error in Family-Based Association Testing.
Genetic epidemiology - 1 Dec 2025
Day Tyler R C, Bis Joshua C, Chapman Nicola, Nato Alejandro Q, Horimoto Andrea R V R, Sohi Harkirat, Nafikov Rafael, Blue Elizabeth E, Saad Mohamad, Wijsman Ellen M
Abstract excerpt
Genotype imputation is a widely-used data augmentation approach that is applied to samples of related and/or unrelated individuals. Association testing may then be carried out on the complete data with commonly-used methods. This approach has typically not accounted for the mix of observed and imputed data, although recent work has noted the potential for introduction of confounding in case-control studies. In...
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