Article
The relationship between imputation error and statistical power in genetic association studies in diverse populations.
American journal of human genetics - 1 Nov 2009
Huang Lucy, Wang Chaolong, Rosenberg Noah A
Abstract excerpt
Genotype-imputation methods provide an essential technique for high-resolution genome-wide association (GWA) studies with millions of single-nucleotide polymorphisms. For optimal design and interpretation of imputation-based GWA studies, it is important to understand the connection between imputation error and power to detect associations at imputed markers. Here, using a 2x3 chi-square test, we describe a...
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