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Article

Value of Mendelian laws of segregation in families: data quality control, imputation, and beyond.

Genetic epidemiology - 1 Sept 2014

Blue Elizabeth M, Sun Lei, Tintle Nathan L, Wijsman Ellen M

Abstract excerpt

When analyzing family data, we dream of perfectly informative data, even whole-genome sequences (WGSs) for all family members. Reality intervenes, and we find that next-generation sequencing (NGS) data have errors and are often too expensive or impossible to collect on everyone. The Genetic Analysis Workshop 18 working groups on quality control and dropping WGSs through families using a genome-wide association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25112184
DOI: 10.1002/gepi.21821
PMCID: PMC4135526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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