Article
A new statistic to evaluate imputation reliability.
PloS one - 15 Mar 2010
Lin Peng, Hartz Sarah M, Zhang Zhehao, Saccone Scott F, Wang Jia, Tischfield Jay A, Edenberg Howard J, Kramer John R, M Goate Alison, Bierut Laura J, Rice John P
Abstract excerpt
BACKGROUND: As the amount of data from genome wide association studies grows dramatically, many interesting scientific questions require imputation to combine or expand datasets. However, there are two situations for which imputation has been problematic: (1) polymorphisms with low minor allele f...
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