Article
When Does Choice of Accuracy Measure Alter Imputation Accuracy Assessments?
PloS one - 1 Jan 2015
Ramnarine Shelina, Zhang Juan, Chen Li-Shiun, Culverhouse Robert, Duan Weimin, Hancock Dana B, Hartz Sarah M, Johnson Eric O, Olfson Emily, Schwantes-An Tae-Hwi, Saccone Nancy L
Abstract excerpt
Imputation, the process of inferring genotypes for untyped variants, is used to identify and refine genetic association findings. Inaccuracies in imputed data can distort the observed association between variants and a disease. Many statistics are used to assess accuracy; some compare imputed to genotyped data and others are calculated without reference to true genotypes. Prior work has shown that the Imputation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.