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Article

DISSCO: direct imputation of summary statistics allowing covariates.

Bioinformatics (Oxford, England) - 1 Aug 2015

Xu Zheng, Duan Qing, Yan Song, Chen Wei, Li Mingyao, Lange Ethan, Li Yun

Abstract excerpt

BACKGROUND: Imputation of individual level genotypes at untyped markers using an external reference panel of genotyped or sequenced individuals has become standard practice in genetic association studies. Direct imputation of summary statistics can also be valuable, for example in meta-analyses where individual level genotype data are not available. Two methods (DIST and ImpG-Summary/LD), that assume a...

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PMID: 25810429
DOI: 10.1093/bioinformatics/btv168
PMCID: PMC4514926

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