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Article

Genetic resilience to chronic obstructive pulmonary disease is a clinically distinct subtype in individuals with cigarette smoke exposure.

Respiratory research - 28 Oct 2025

Ghosh Auyon J, Chang Ko-Yun, Moll Matthew, Hess Jonathan, Coyne Liam P, Panda Sanchit, Cho Michael H, Bowler Russell P, Glatt Stephen J, Hersh Craig P

Abstract excerpt

BACKGROUND: There is substantial unexplained variability in the development of disease. A genetic risk score for COPD identifies individuals at markedly elevated risk of COPD; however, many high-genetic risk individuals do not develop disease. We sought to define genetic resilience in COPD by identifying and characterizing individuals who are resistant to their elevated genetic susceptibility. METHODS: We defined...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41152839
DOI: 10.1186/s12931-025-03380-w
PMCID: PMC12560536

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