Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts.

doi:10.1164/rccm.202401-0127OC

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Article

Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts.

American journal of respiratory and critical care medicine - 1 Apr 2025

Bell Alexander J, Ram Sundaresh, Labaki Wassim W, Murray Susan, Kazerooni Ella A, Galban Stefanie, Martinez Fernando J, Hatt Charles R, Wang Jennifer M, Ivanov Vladimir, McGettigan Paul, Khokhlovich Edward, Maiorino Enrico, Suryadevara Rahul, Boueiz Adel, Castaldi Peter J, Mirkes Evgeny M, Zinovyev Andrei, Gorban Alexander N, Galban Craig J, Han MeiLan K

Abstract excerpt

Rationale: Chronic obstructive pulmonary disease (COPD) exhibits considerable progression heterogeneity. We hypothesized that elastic principal graph analysis (EPGA) would identify distinct clinical phenotypes and their longitudinal relationships. Objectives: Our primary objective was to create a map of COPD phenotypes and their connectivity using EPGA. Secondarily, we used longitudinal and external data sets to...

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PMID: 39269427
DOI: 10.1164/rccm.202401-0127OC
PMCID: PMC12005034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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