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Article

Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492.

Journal of mammary gland biology and neoplasia - 1 Dec 2021

Sigurdardottir Anna Karen, Jonasdottir Arna Steinunn, Asbjarnarson Arni, Helgudottir Hildur Run, Gudjonsson Thorarinn, Traustadottir Gunnhildur Asta

Abstract excerpt

The human breast is composed of terminal duct lobular units (TDLUs) that are surrounded by stroma. In the TDLUs, basement membrane separates the stroma from the epithelial compartment, which is divided into an inner layer of luminal epithelial cells and an outer layer of myoepithelial cells. Stem cells and progenitor cells also reside within the epithelium and drive a continuous cycle of gland remodelling that...

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Identifiers

PMID: 34964086
DOI: 10.1007/s10911-021-09507-1
PMCID: PMC8858314

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