Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response.

doi:10.1016/j.celrep.2025.116478

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Article

Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response.

Cell reports - 25 Nov 2025

Elliot Abigail M, Ribeiro Bravo Isabel, Zhao Yiyi, Wang Zhuorui, Astorga Johansson Jeanette, Hutton Esme, Cunningham Richard, Myllymäki Henna, Chang Kai Yee, Cholewa-Waclaw Justyna, Kelly Lisa, Beltran Mariana, Lewis Amy, Elks Philip M, Hansen Carsten Gram, Henderson Neil C, Feng Yi

Abstract excerpt

Oncogenic driver mutations are common in normal tissues, indicating that non-genetic factors are necessary for tumorigenesis. Phenotypic plasticity is a crucial gateway to malignancy, and inflammation can fuel tumorigenesis; however, little is known about the timing and mechanisms by which these hallmarks first emerge. Using single-cell transcriptomics and in vivo live imaging, we characterized the immediate...

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Topics

Animals
Zebrafish
Neutrophils
Humans
Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Keratinocytes

Proto-Oncogene Proteins p21(ras)

Skin Neoplasms

Cell Plasticity

Carcinogenesis

ras Proteins

Cell Proliferation

Source

Open in PubMed

Identifiers

PMID: 41138187
DOI: 10.1016/j.celrep.2025.116478

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