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Article

Causal association between matrix metalloproteinases and gout: A two-sample mendelian randomization study.

The American journal of the medical sciences - 1 Jan 2026

Chen Da-Wei, Hu Gaohua, Mao Li, Wang Guoying, Tian Yu, He Jinxing, Qian Shenyu, Yang Wenyu, Zheng Yinshuang, Lin Lijin, Pei Wei

Abstract excerpt

BACKGROUND: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of gout. However, the causal nature of their associations remains unclear. This study aimed to evaluate the potential causal effects of MMPs on gout. METHODS: The study was performed using two-sample Mendelian randomization (MR) analyses with publicly available genome-wide association study (GWAS) summary statistics of ten MMP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41120089
DOI: 10.1016/j.amjms.2025.10.006

Genes

MMP3
MMP9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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