Metalloproteins as risk factors for osteoarthritis: improving and understanding causal estimates using Mendelian randomization.

Abstract excerpt

Osteoarthritis (OA) is one of the most prevalent musculoskeletal disorders and a primary cause of pain and disability among the elderly population. Research on the relationship between metalloproteins (MPs) and OA is limited, and causality remains unclear. Our objective is to utilize Mendelian randomization (MR) to explore the possible causal relationship between MPs and OA. The data on MPs were derived from a...

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• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Osteoarthritis
• Polymorphism, Single Nucleotide