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Article

The causal relationship between matrix metalloproteinase-3 and fibromyalgia: A two-sample Mendelian randomization analysis.

Medicine - 12 Sept 2025

Wang Honglin, Zhou Hong, Cai Yifan, Ye Zhewei

Abstract excerpt

Fibromyalgia is a chronic pain syndrome with incompletely understood pathogenesis. Matrix metalloproteinase-3 (MMP-3), a key enzyme involved in inflammation and tissue remodeling, has not been genetically validated for its causal relationship with fibromyalgia. This study aims to explore the causal association between MMP-3 and fibromyalgia using Mendelian randomization (MR) methods. Genome-wide association study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40958320
DOI: 10.1097/MD.0000000000044420
PMCID: PMC12440400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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