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Article

Causal relationship between matrix metalloproteinase and pulmonary embolism: a bidirectional two-sample Mendelian randomization study.

Scientific reports - 2 Jan 2025

Gong Xiaowei, Yuan Yadong

Abstract excerpt

This study evaluated the causal relationship between matrix metalloproteinases (MMPs) and pulmonary embolism using data from the genome-wide association study (GWAS) of pulmonary embolism from the UK Biobank and a GWAS dataset of MMPs based on 5,457 Icelanders aged 65 years and older. MR-Egger, MR-PRESSO, Cochran's Q, and leave-one-out were used for sensitivity analysis. The Mendelian randomization (MR) analysis,...

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Aged
Genetic Predisposition to Disease
Genome-Wide Association Study
Matrix Metalloproteinases
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Pulmonary Embolism

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Identifiers

PMID: 39747197
DOI: 10.1038/s41598-024-83735-3
PMCID: PMC11697021

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