Evaluating the Causal Roles of Matrix Metalloproteinases in Metabolic Syndrome: A Mendelian Randomization Study Highlighting MMP12 in Blood Pressure Regulation.

Abstract excerpt

PURPOSE: This study aims to investigate whether matrix metalloproteinases (MMPs) are associated with the risk of metabolic syndrome (MetS) and its components. METHODS: We conducted a two-sample Mendelian randomization (MR) study by using 9 types of MMPs as exposures and MetS and its components (waist circumference, essential hypertension, fasting blood glucose [FBG], high-density lipoprotein [HDL] cholesterol,...

Topics

• Metabolic Syndrome
• Mendelian Randomization Analysis
• Humans
• Blood Pressure
• Matrix Metalloproteinase 12
• Genome-Wide Association Study