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Article

Analytical and computational solution for the estimation of SNP-heritability in biobank-scale and distributed datasets.

PLoS computational biology - 1 Oct 2025

Qi Guo-An, Zhang Qi-Xin, Kang Jingyu, Li Tianyuan, Xu Xiyun, Zhang Zhe, Fan Zhe, Liu Siyang, Chen Guo-Bo

Abstract excerpt

For a complex trait, heritability ([Formula: see text]) gives the genetic determination of its variation. Given the emergence of biobank-scale data, a more powerful method is needed to estimate [Formula: see text]. Based on the framework of Haseman-Elston regression (RHE-reg), we integrate a fast randomization algorithm to estimate [Formula: see text], and RHE-reg can tackle biobank-scale data, such as UK Biobank...

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Identifiers

PMID: 41118419
DOI: 10.1371/journal.pcbi.1013568
PMCID: PMC12539748

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