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Article

Estimating SNP heritability in presence of population substructure in biobank-scale datasets.

Genetics - 4 Apr 2022

Lin Zhaotong, Seal Souvik, Basu Saonli

Abstract excerpt

Single nucleotide polymorphism heritability of a trait is measured as the proportion of total variance explained by the additive effects of genome-wide single nucleotide polymorphisms. Linear mixed models are routinely used to estimate single nucleotide polymorphism heritability for many complex traits, which requires estimation of a genetic relationship matrix among individuals. Heritability is usually estimated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait, Heritable

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Identifiers

PMID: 35106569
DOI: 10.1093/genetics/iyac015
PMCID: PMC8982037

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