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Article

UK BioCoin: swift trait-specific summary statistics regression for UK Biobank.

Nature communications - 17 Apr 2026

He Jingcheng, Qi Guoan, Ying Jiacheng, Qian Yu, Gu Lin-Lin, Zhang Qi-Xin, Han Lide, Mao Yingying, Zheng Hou-Feng, Jiang Hangjin, Chen Guo-Bo

Abstract excerpt

statistics derived from large-scale biobanks facilitate the sharing of genetic discoveries but are typically limited by fixed covariate adjustments, preventing the exploration of trait-specific adjustments. Here we present UK BioCoin (UKC), a computational device designed to enable efficient, user-specified covariate adjustment without requiring access to individual-level data. Using the UK Biobank (505 unique...

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Identifiers

PMID: 41997943
DOI: 10.1038/s41467-026-71788-z
PMCID: PMC13276075

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