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HLA-DRB1*15:01 drives sex- and age-dependent microglial activation and neuroimmune signaling

2026-03-14

Abstract excerpt

<h4>Introduction</h4> The major histocompatibility complex class II (MHC-II) pathway is central to adaptive immunity and immune tolerance, and age-related erosion of these mechanisms is increasingly recognized as a driver of chronic neuroinflammation. The HLA-DRB1*15:01 allele—the strongest genetic risk factor for multiple sclerosis in Caucasians—has been implicated in shaping pathogenic CD4⁺ T-cell responses and...

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Literature Corpus work
fcfff13c-ad63-5f53-878f-e5841c7c28fe
DOI
10.64898/2026.03.11.711132
Open publication

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