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Article

DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.

Diabetologia - 1 Oct 2021

Thomas Nicholas J, Dennis John M, Sharp Seth A, Kaur Akaal, Misra Shivani, Walkey Helen C, Johnston Desmond G, Oliver Nick S, Hagopian William A, Weedon Michael N, Patel Kashyap A, Oram Richard A

Abstract excerpt

AIMS/HYPOTHESIS: Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought to quantify DR15-DQ6 protection against type 1 diabetes as age of onset...

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Identifiers

PMID: 34272580
DOI: 10.1007/s00125-021-05513-4
PMCID: PMC8423681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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