Article
Detecting polymorphisms in human longevity studies: HLA typing and SNP genotyping by amplicon sequencing.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Vargas-Alarcón Gilberto, Flores-Domínguez Carmina
Abstract excerpt
Life expectancy has always been associated to several determinants, such as environmental and genetic factors. Studies have related human lifespan as being 25-32 % due to genetic polymorphisms between individuals associated to longevity and aging. Nonetheless, no single gene will convey a phenotype like longevity. Aging is a process that occurs from changes in various levels of the cell, from genes to functions....
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