Article
Spike residue 403 affects binding of coronavirus spikes to human ACE2.
Nature communications - 25 Nov 2021
Zech Fabian, Schniertshauer Daniel, Jung Christoph, Herrmann Alexandra, Cordsmeier Arne, Xie Qinya, Nchioua Rayhane, Prelli Bozzo Caterina, Volcic Meta, Koepke Lennart, Müller Janis A, Krüger Jana, Heller Sandra, Stenger Steffen, Hoffmann Markus, Pöhlmann Stefan, Kleger Alexander, Jacob Timo, Conzelmann Karl-Klaus, Ensser Armin, Sparrer Konstantin M J, Kirchhoff Frank
Abstract excerpt
The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, the cause of the COVID-19 pandemic. However, this bat virus was most likely unable to directly infect humans since its Spike (S) protein does not interact efficiently with the human ACE2 receptor. Here, we show that a single T403R mutation increases binding of RaTG13 S to human ACE2 and allows VSV pseudoparticle infection of human lung cells and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.