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Article

Distinct pathways for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses

15 Nov 2024

Abstract excerpt

Understanding the zoonotic risks posed by bat coronaviruses (CoVs) is critical for pandemic preparedness. Herein, we generated recombinant vesicular stomatitis viruses (rVSVs) bearing spikes from divergent bat CoVs to investigate their cell entry mechanisms. Unexpectedly, the successful recovery of rVSVs bearing the spike from SHC014-CoV, a SARS-like bat CoV, was associated with the acquisition of a novel...

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PMID: 39546542
DOI: 10.1371/journal.ppat.1012704

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