Relationship Between Phenotyping and Individualized Absolute Risk Differences in Sepsis: A Secondary Analysis of Two Approaches in Two Multicenter Trials.

doi:10.1097/CCE.0000000000001332

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Article

Relationship Between Phenotyping and Individualized Absolute Risk Differences in Sepsis: A Secondary Analysis of Two Approaches in Two Multicenter Trials.

Critical care explorations - 1 Oct 2025

Talisa Victor B, Yende Sachin P, Angus Derek C, Bellomo Rinaldo, Chang Chung-Chou H, Cooper Gregory F, Harrison David A, Higgins Alisa, Kennedy Jason N, Mayr Florian B, Mouncey Paul, Peake Sandra L, Rowan Kathy, Tang Lu, Triantafyllou Sofia, Yealy Donald M, Seymour Christopher W, Shah Faraaz Ali

Abstract excerpt

OBJECTIVES: Sepsis trials likely include patients who vary in response to therapeutic interventions. The optimal approach to identify such differences in treatment response remains unclear. Estimating individualized absolute risk differences (iARDs) to model treatment response at an individual patient level using supervised effect models applied to randomized trial data may be informative. We explored the...

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Topics

Humans
Phenotype
Male
Sepsis
Shock, Septic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Middle Aged

Aged

Early Goal-Directed Therapy

Precision Medicine

Resuscitation

Biomarkers

Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 41098209
DOI: 10.1097/CCE.0000000000001332
PMCID: PMC12520220

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