Article
Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation.
American journal of respiratory and critical care medicine - 1 Sept 2025
Kiernan Elizabeth, Zelnick Leila R, Khader Ayesha, Coston Taylor D, Bailey Zoie A, Speckmaier Sarah, Lo Jordan J, Siew Edward D, Sathe Neha A, Kestenbaum Bryan R, Himmelfarb Jonathan, Johnson Nicholas J, Shapiro Nathan I, Douglas Ivor S, Hough Catherine L, Bhatraju Pavan K
Abstract excerpt
Rationale: Biological heterogeneity in critical illness syndromes, such as sepsis and acute kidney injury (AKI), has hindered development of effective therapies. In sepsis-associated AKI, two molecular subphenotypes (SP1 and SP2) have been identified with differing characteristics, outcomes, and response to vasopressor treatment. It is unknown if these subphenotypes extend to all patients with sepsis and whether...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.