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Article

Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial.

Scientific reports - 14 Mar 2024

DeMerle Kimberley M, Kennedy Jason N, Chang Chung-Chou H, Delucchi Kevin, Huang David T, Kravitz Max S, Shapiro Nathan I, Yealy Donald M, Angus Derek C, Calfee Carolyn S, Seymour Christopher W

Abstract excerpt

Sepsis is a heterogeneous syndrome and phenotypes have been proposed using clinical data. Less is known about the contribution of protein biomarkers to clinical sepsis phenotypes and their importance for treatment effects in randomized trials of resuscitation. The objective is to use both clinical and biomarker data in the Protocol-Based Care for Early Septic Shock (ProCESS) randomized trial to determine sepsis...

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Identifiers

PMID: 38485953
DOI: 10.1038/s41598-024-55667-5
PMCID: PMC10940677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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