A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure.

doi:10.1186/s13073-025-01547-0

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Article

A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure.

Genome medicine - 15 Oct 2025

Conil Clément, Bohlen Jonathan, Kroon Elouise E, Jean-Juste Marc A, Manry Jérémy, Chaldebas Matthieu, Bean James M, Walsh Kathleen F, Dallmann-Sauer Monica, Rotival Maxime, Seeleuthner Yoann, Marchal Astrid, Mourelatos Haralambos, Fava Vinicius M, Zhang Peng, Kerner Gaspard, Skhoun Hanaa, Abid Ahmed, El Ouazzani Hanane, Rafik Aniss, Bousfiha Ahmed Aziz, El Baghdadi Jamila, Wilkinson Robert J, Boisson-Dupuis Stéphanie, Fitzgerald Daniel W, Pape Jean W, Möller Marlo, Hoal Eileen G, Casanova Jean-Laurent, Abel Laurent, Schurr Erwin, Cobat Aurélie

Abstract excerpt

BACKGROUND: Despite sustained exposure to Mycobacterium tuberculosis (Mtb), some individuals-so-called resisters-have persistently negative results for the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs). "Resistance to immune conversion" is the best-known clinical correlate for absence of Mtb transmission and protection from tuberculosis (TB). We investigated the human genetic basis of...

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Identifiers

PMID: 41094526
DOI: 10.1186/s13073-025-01547-0
PMCID: PMC12522460

Genes

YEATS4
TST

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