Article
Resistance to TST/IGRA conversion in Uganda: Heritability and Genome-Wide Association Study.
EBioMedicine - 1 Dec 2021
McHenry Michael L, Benchek Penelope, Malone LaShaunda, Nsereko Mary, Mayanja-Kizza Harriet, Boom W Henry, Williams Scott M, Hawn Thomas R, Stein Catherine M
Abstract excerpt
BACKGROUND: Pulmonary tuberculosis (TB) is one of the most deadly pathogens on earth. However, the majority of people have resistance to active disease. Further, some individuals, termed resisters (RSTRs), do not develop traditional latent tuberculosis (LTBI). The RSTR phenotype is important for understanding pathogenesis and preventing TB. The host genetic underpinnings of RSTR are largely understudied. METHODS:...
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