A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals.

doi:10.1016/j.ajhg.2016.01.015

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Article

A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals.

American journal of human genetics - 3 Mar 2016

Sobota Rafal S, Stein Catherine M, Kodaman Nuri, Scheinfeldt Laura B, Maro Isaac, Wieland-Alter Wendy, Igo Robert P, Magohe Albert, Malone LaShaunda L, Chervenak Keith, Hall Noemi B, Modongo Chawangwa, Zetola Nicola, Matee Mecky, Joloba Moses, Froment Alain, Nyambo Thomas B, Moore Jason H, Scott William K, Lahey Timothy, Boom W Henry, von Reyn C Fordham, Tishkoff Sarah A, Sirugo Giorgio, Williams Scott M

Abstract excerpt

Immunosuppression resulting from HIV infection increases the risk of progression to active tuberculosis (TB) both in individuals newly exposed to Mycobacterium tuberculosis (MTB) and in those with latent infections. We hypothesized that HIV-positive individuals who do not develop TB, despite living in areas where it is hyperendemic, provide a model of natural resistance. We performed a genome-wide association...

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Identifiers

PMID: 26942285
DOI: 10.1016/j.ajhg.2016.01.015
PMCID: PMC4800052

Genes

IL12B
CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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