Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis.

doi:10.1038/s41590-024-01897-8

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Article

Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis.

Nature immunology - 1 Aug 2024

Sun Meng, Phan Jolie M, Kieswetter Nathan S, Huang Huang, Yu Krystle K Q, Smith Malisa T, Liu Yiran E, Wang Chuangqi, Gupta Sanjana, Obermoser Gerlinde, Maecker Holden Terry, Krishnan Akshaya, Suresh Sundari, Gupta Neha, Rieck Mary, Acs Peter, Ghanizada Mustafa, Chiou Shin-Heng, Khatri Purvesh, Boom W Henry, Hawn Thomas R, Stein Catherine M, Mayanja-Kizza Harriet, Davis Mark M, Seshadri Chetan

Abstract excerpt

A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) that we refer to as 'resisters' (RSTR) show evidence of IFN-γ- T cell responses to Mtb-specific antigens despite serially negative results on clinical testing. Here we found that Mtb-specific T cells in RSTR were clonally expanded, confirming the priming of adaptive immune responses following Mtb exposure. RSTR CD4+ T cells showed enrichment of...

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Identifiers

PMID: 38997431
DOI: 10.1038/s41590-024-01897-8
PMCID: PMC11291275

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