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Distribution of HLA class I and II genetic profiles of Indian population: A regional analysis using 30,027 umbilical cord blood samples.

Human immunology - 1 Nov 2025

Rajendran Sureka, Sivadas Ambily, Ganesan Kanaga, Gutjahr Georg, Murugan Alagupandian, Chaturvedi Ankur, Phani Nagaraja S, Padhiar Chirayu, Gambhir Prakash Sadashiv

Abstract excerpt

Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells for treating life-threatening haematological disorders. India's vast population, known for its cultural, linguistic, and genetic diversity, requires a significant need for HLA-matched donors. We analyzed HLA-A, -B, -C, -DRB1, and -DQB1 allele and haplotype diversity in 30,027 UCB units. Samples were categorized into six broad regional...

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PMID: 41092694
DOI: 10.1016/j.humimm.2025.111600

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