Study of human leukocyte antigen (HLA) allele and haplotype frequency using next generation sequencing (NGS) platform: Single-centre study of over 500 individuals in India!

doi:10.1016/j.trim.2025.102180

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Study of human leukocyte antigen (HLA) allele and haplotype frequency using next generation sequencing (NGS) platform: Single-centre study of over 500 individuals in India!

Transplant immunology - 1 Mar 2025

Simmi Mehra, Tiwari Aseem K, Rajni Chauhan, Gunjan Bhardwaj, Neha Rani, Shubham Kashyap, Simran Kahlon

Abstract excerpt

BACKGROUND: The huge diversity of Human Leukocyte Antigen (HLA) system is well-known to be associated with various diseases, anthropology, population genetics, and transplantation. The frequencies of HLA alleles in different populations are crucial for both research and clinical applications. This study determined the allelic and haplotype frequencies of all HLA class I and class II loci in 595 consecutive...

Read the complete abstract on PubMed

Topics

Humans
Haplotypes
India
High-Throughput Nucleotide Sequencing
Gene Frequency
Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HLA Antigens

Alleles

Histocompatibility Testing

Organ Transplantation

Male

Female

Adult

Source

Open in PubMed

Identifiers

PMID: 39892763
DOI: 10.1016/j.trim.2025.102180

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