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HLA match probability in Indian regional population using umbilical cord blood units: Implications for optimal registry size and targeted donor recruitment.

Human immunology - 1 Oct 2026

Rajendran Sureka, Sivadas Ambily, Sidharthan Neeraj, Gutjar Georg, Ganesan Kanaga, Joshi Anupam, Chaturvedi Ankur, Gambir Prakash Sadashiv, Phani Nagarajan M

Abstract excerpt

Human leukocyte antigen matched unrelated donor (URD) identification remains a major challenge for Indian patients due to high genetic diversity and endogamy. Utilizing a HLA high-resolution dataset of 30,027 umbilical cord blood (UCB) units, this study modeled 10/10 and 8/8 matching probabilities for five broad regions and nine sub-regional linguistic populations. Two statistical frameworks, the Formula Matching...

Read the complete abstract on PubMed

Topics

Humans
Registries
India
HLA Antigens
Fetal Blood
Histocompatibility Testing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Probability

Alleles

Unrelated Donors

Source

Identifiers

PMID: 42617408
DOI: 10.1016/j.humimm.2026.112044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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