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Article

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease.

Annals of clinical and translational neurology - 1 Mar 2026

Jin Tingru, Yang Haocheng, Liu Feng, Lin Sihao, Hu Junru, Wang Jian, Gou Yulan

Abstract excerpt

BACKGROUND: Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and dyslipidemia in CSVD patients, and to explore whether lipid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41089070
DOI: 10.1002/acn3.70224
PMCID: PMC12968454

Genes

APOE
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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