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Article

The dual role of APOE ε4 allele in cerebral small vessel disease: independent genetic effects and effect modification of traditional risk factors.

Frontiers in neurology - 1 Jan 2026

Liu Feng, Gou Yulan

Abstract excerpt

Background: The association between apolipoprotein E (APOE) ε4 and cerebral small vessel disease (CSVD) remains incompletely understood, with inconsistent evidence across imaging phenotypes and limited investigation into gene-environment interactions. Method: This cross-sectional study included 728 patients with chronic lacunar infarcts who underwent 3 T brain MRI. CSVD burden was quantified using a...

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Identifiers

PMID: 42620841
DOI: 10.3389/fneur.2026.1778289
PMCID: PMC13485915

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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