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Article

Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2018

Stefaniak James D, Su Li, Mak Elijah, Sheikh-Bahaei Nasim, Wells Katie, Ritchie Karen, Waldman Adam, Ritchie Craig W, O'Brien John T

Abstract excerpt

INTRODUCTION: Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOE ε4) and LOAD, in older people. However, it is unclear whether CSVD begins in middle age in individuals genetically predisposed to LOAD. METHODS: We assessed the relationship between radiological markers of CSVD, white matter...

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Source

Identifiers

PMID: 29156222
DOI: 10.1016/j.jalz.2017.08.017

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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