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Article

The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia.

Journal of translational medicine - 14 Oct 2025

Wang Zheng, Li Lu, Xu Qian, Pan Hongxu, Wang Yijing, Long Qin, Huang Yuanfeng, Dai Yinghong, Zhang Shiyu, Zhou Qiao, Zhao Guihu, Li Bin, Tang Beisha, Qiu Jian, Li Jinchen

Abstract excerpt

BACKGROUND: Patients with Parkinson's disease (PD) tend to have a shorter life expectancy compared to the general population. While the genetic architecture significantly influences individual variability in survival among these patients with PD, the contributions of most genetic variations to this heterogeneity remain unclear. METHODS: The study included 2365 living and 1575 deceased unrelated White European PD...

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Source

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Identifiers

PMID: 41088299
DOI: 10.1186/s12967-025-07169-9
PMCID: PMC12522874

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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