Article
Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia.
Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2006
Pankratz Nathan, Byder Lisa, Halter Cheryl, Rudolph Alice, Shults Clifford W, Conneally P Michael, Foroud Tatiana, Nichols William C
Abstract excerpt
The epsilon4 allele of the apolipoprotein E gene (APOE4) has been consistently associated with a greater risk of Alzheimer's disease (AD) as well as an earlier onset of AD. It is possible that APOE4 may also play a role in the etiology of other neurodegenerative disorders, such as Parkinson's disease (PD). APOE genotype, age of onset, disease duration, smoking history, and dementia status were collected for...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Female
- Genetic Carrier Screening