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Article

Alzheimer disease associated variants in SORL1 accelerate dementia development in Parkinson disease.

Neuroscience letters - 1 May 2018

Maple-Grødem Jodi, Chung Janete, Lunde Kristin Aaser, Tzoulis Charalampos, Tysnes Ole-Bjørn, Pedersen Kenn Freddy, Alves Guido

Abstract excerpt

OBJECTIVE: Dementia in Parkinson disease (PD) is a common occurrence, and shows a marked overlap at a clinical and pathological level with Alzheimer's disease (AD), suggesting they share underlying disease mechanisms. Genetic variants in SORL1 have been identified in patients with AD, but a possible role in other dementias is unknown. The aim of this study was to investigate whether common polymorphisms in SORL1...

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Source

Identifiers

PMID: 29567423
DOI: 10.1016/j.neulet.2018.03.036

Genes

SORL1

Variants

rs2298813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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